Korean J Blood Transfus.  2015 Dec;26(3):291-299. 10.17945/kjbt.2015.26.3.291.

Korean Red Cross HLA-Matched Platelet Donor Registry

• Kwon SY
• Lee SA
• Lim AH
• Cho NS
• Jung CH
• Yang JH
• Park KU

• KMID: 2139794
• DOI: http://doi.org/10.17945/kjbt.2015.26.3.291

Abstract

BACKGROUND
Transfusion of HLA-matched platelets is required when development of platelet refractoriness occurs after repeated platelet transfusion. This study was conducted to establish a HLA-matched platelet donor registry to supply matched platelets to patients who develop platelet refractoriness.
METHODS
HLA-matched platelet donors were recruited among plateletpheresis donors. HLA-A and HLA-B antigen types of recruited donors were tested using a polymerase chain reaction-sequence specific oligonucleotide probe method.
RESULTS
A total of 1,029 plateletpheresis donors were recruited. HLA-A and HLA-B antigen frequencies of recruited donors were similar to those of previously reported HLA antigen frequencies of Koreans. During the study period, a patient with platelet refractoriness recovered after receiving six units of HLA-matched platelets.
CONCLUSION
During this study 1,029 donors were registered as HLA-matched platelet donors and a patient with platelet refractoriness received HLA-matched platelets using this registry. Supply of HLA-matched platelets will be facilitated by continuous expansion of the number of registered HLA-matched platelet donors, development of a program for management and searching for HLA-matched donors, and establishment of a request-supply system between hospitals and the Korean Red Cross through further studies.

Keyword

HLA-matched platelet; Donor registry; Platelet refractoriness

MeSH Terms

Blood Platelets*
HLA-A Antigens
HLA-B Antigens
Humans
Platelet Transfusion
Plateletpheresis
Red Cross*
Tissue Donors*
HLA-A Antigens
HLA-B Antigens