J Korean Bone Joint Tumor Soc.  2011 Jun;17(1):17-22. 10.5292/jkbjts.2011.17.1.17.

Chondrosarcoma Arising from Benign Bone Tumor due to Malignant Transformation

• Cho WH
• Song WS
• Kong CB
• Hong YS
• Lee JD
• Jeon DG

• KMID: 2137039
• DOI: http://doi.org/10.5292/jkbjts.2011.17.1.17

Abstract

PURPOSE
We analyzed the oncological outcome and prognostic factor of the chondrosarcoma arising from benign bone tumor due to malignant transformation.
MATERIALS AND METHODS
From April 1986 to April 2009, 18 cases were considered eligible. We analyzed retrospectively the patient's characteristics and prognostic factors that affect to the local recurrence and distant metastasis.
RESULTS
As classified by primary benign bone tumor, 4 cases were solitary osteochondroma, 11 cases were multiple osteochondromatosis and 3 cases were multiple enchondromatosis. The mean follow-up period was 85 months. The 5-year disease free survival rate of 18 patients was 85.9%. Their overall MSTS score was 25.2 (84%). There were local recurrence in 3 cases and no distant metastasis. We found that tumor location and surgical margin affected to the prognosis significantly.
CONCLUSION
In secondary chondrosarcoma patients, the prognosis was good relatively and tumor location and surgical margin are important prognosis factor.

Keyword

chondrosarcoma; maliganant transformation; prognostic factor

MeSH Terms

Chondrosarcoma
Disease-Free Survival
Enchondromatosis
Follow-Up Studies
Humans
Neoplasm Metastasis
Osteochondroma
Osteochondromatosis
Prognosis
Recurrence
Retrospective Studies

Figure

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  Figure 1. Patient was a 30-year old man who was diagnosed as Oiller's disease. (A) Bone scan shows multiple irregular uptakes. (B) This MRI was taken just before incisional biopsy. On the T1W1 MRI image, there are mixed low-high SI on T2WI and heterogeneous enhancement in both hip bones and proximal femurs. (C) Preoperative radiograph shows osteolytic bony destruction of right acetabulum, ischium and superior pubic ramus. (D) This radiograph was eight months after curettage and bone cementation. The patients is alive with disease.

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