J Korean Acad Rehabil Med.  2001 Apr;25(2):341-347.

Clinical and Electrophysiologic Features in Four Cases of Castleman's Disease with Peripheral Polyneuropathy

• Han TR
• Chung SG
• Jeon JY

Abstract

Castleman's disease is a rare clinicopathological entity characterized by multicentric angiofollicular lymph node hyperplasia and sometimes associated with polyneuropathy. We report 4 cases identified with diagnosis of Castleman's disease by lymph node biopsy and peripheral polyneuropathy. They had a hypesthesia of all limbs, gait disturbance, weakness of distal lower limbs and enlargement of lymph nodes. Among them 2 patients were combined with POEMS (polyneuropathy, organomegaly, endocrinopathy, increase of M protein, skin change) syndrome. Motor and sensory nerve conduction velocities were below 70% of lower normal limit, the amplitudes of compound muscle action potential (CMAP) and sensory nerve action potential (SNAP) were reduced. Deterioration of nerve conduction study was more severe in lower limb than the upper. More denervation potentials were found in lower limbs than the upper and in distal limbs than the proximal. As disease getting worse, the slower conduction velocity and lower amplitude of CMAP and SNAP were observed.

Keyword

Castleman's disease; Electrophysiologic features; Polyneuropathy

MeSH Terms

Action Potentials
Biopsy
Denervation
Diagnosis
Extremities
Gait
Giant Lymph Node Hyperplasia*
Humans
Hypesthesia
Lower Extremity
Lymph Nodes
Neural Conduction
Polyneuropathies*
Skin