Gut Liver.  2013 Mar;7(2):197-205.

The Efficacy and Safety of Peginterferon-alpha-2a in Korean Patients with Chronic Hepatitis B: A Multicenter Study Conducted in a Real Clinical Setting

• Kwon JH
• Kim YS
• Kim SG
• Jang JW
• Kim TH
• Jung YK
• Kwon OS

Abstract

BACKGROUND/AIMS
Genotype C is the principal type of hepatitis B virus (HBV) in Koreans and is associated with poor prognosis for peginterferon alpha-2a therapy. The efficacy of and compliance to peginterferon alpha-2a therapy were investigated in Koreans with hepatitis B in a real clinical setting.
METHODS
Hepatitis B patients treated with peginterferon alpha-2a from 2008 to 2011 at four university hospitals were consecutively enrolled.
RESULTS
Eighty-eight patients were enrolled; 67 were hepatitis B e antigen (HBeAg)-positive. The mean treatment period was 36.1+/-15.2 weeks. In 26.1% of patients, treatment was discontinued due to insufficient antiviral effects and adverse events. At 24 weeks after treatment, 10/42 (23.8%) HBeAg-positive patients achieved both HBV DNA suppression to <2,000 IU/mL and HBeAg loss/seroconversion. For HBeAg-negative patients, 10/13 (76.9%) achieved HBV DNA suppression to <2,000 IU/mL at 24 weeks after treatment. During the follow-up period, 15 (30.6%) of the 49 patients who achieved HBV DNA suppression to 2,000 IU/mL developed a breakthrough HBV DNA level of >2x10(6) IU/mL.
CONCLUSIONS
Peginterferon alpha-2a therapy in Koreans with hepatitis B in a real clinical setting resulted in a lower virologic response, as compared to Western individuals, but a favorable durability. There is a need to reduce the high rate of premature discontinuation compared to the controlled studies.

Keyword

Peginterferon; Chronic hepatitis B; Asian continental ancestry group

MeSH Terms

Asian Continental Ancestry Group
Compliance
DNA
Follow-Up Studies
Genotype
Hepatitis B
Hepatitis B e Antigens
Hepatitis B virus
Hepatitis B, Chronic
Hepatitis, Chronic
Hospitals, University
Humans
Prognosis
DNA
Hepatitis B e Antigens