Korean J Hepatobiliary Pancreat Surg.  2015 Nov;19(4):133-138. 10.14701/kjhbps.2015.19.4.133.

Calculation of standard liver volume in Korean adults with analysis of confounding variables

• Um EH
• Hwang S
• Song GW
• Jung DH
• Ahn CS
• Kim KH
• Moon DB
• Park GC
• Lee SG

• KMID: 2130964
• DOI: http://doi.org/10.14701/kjhbps.2015.19.4.133

Abstract

BACKGROUNDS/AIMS
Standard liver volume (SLV) is an important parameter that has been used as a reference value to estimate the graft matching in living donor liver transplantation (LDLT). This study aimed to determine a reliable SLV formula for Korean adult patients as compared with the 15 SLV formulae from other studies and further estimate SLV formula by gender and body mass index (BMI).
METHODS
Computed tomography liver volumetry was performed in 1,000 living donors for LDLT and regression formulae for SLV was calculated. Individual donor data were applied to the 15 previously published SLV formulae, as compared with the SLV formula derived in this study. Analysis for confounding variables of BMI and gender was also performed.
RESULTS
Two formulae, "SLV (ml)=908.204xBSA-464.728" with DuBois body surface area (BSA) formula and "SLV (ml)=893.485xBSA-439.169" with Monsteller BSA formula, were derived by using the profiles of the 1,000 living donors included in the study. Comparison with other 15 other formulae, all except for Chouker formula showed the mean volume percentage errors of 4.8-5.4%. The gender showed no significant effect on total liver volume (TLV), but there was a significant increase in TLV as BMI increased.
CONCLUSIONS
Our study suggested that most SLV formulae showed a crudely applicable range of SLV estimation for Korean adults. Considering the volume error in estimating SLV, further SLV studies with larger population from multiple centers should be performed to enhance its predictability. Our results suggested that classifying SLV formulae by BMI and gender is unnecessary.

Keyword

Living donor; Living donor liver transplantation; Standard liver volume; Liver resection

MeSH Terms

Adult*
Body Mass Index
Body Surface Area
Confounding Factors (Epidemiology)*
Humans
Liver Transplantation
Liver*
Living Donors
Reference Values
Tissue Donors
Transplants

Figure

• 

  Fig. 1 Scatter plots showing the correlation between total liver volume and body surface area with DuBois formula (A) and Mosteller formula (B). The solid line indicates the regression equation and the adjacent dotted lines indicate 95% prediction regression bands.

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  Fig. 2 Scatter plots showing the correlation between total liver volume and body surface area in male donors (A) and female donors (B). Solid lines indicate regression equations.

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