J Gynecol Oncol.  2014 Oct;25(4):355-356. 10.3802/jgo.2014.25.4.355.

Bevacizumab in combination with gemcitabine and carboplatin in recurrent ovarian cancer: a critical consideration

Affiliations
  • 1Oncology Unit B, Department of Radiology, Oncology and Human Pathology, Policlinico Umberto I, Sapienza University Rome, Rome, Italy. sagiovannoni@gmail.com

Abstract

No abstract available.


MeSH Terms

*Advisory Committees
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Female
Humans
Neoplasm Recurrence, Local/*radiography
Ovarian Neoplasms/*radiography
Radiology/*standards

Reference

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2. Aghajanian C, Blank SV, Goff BA, Judson PL, Teneriello MG, Husain A, et al. OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. J Clin Oncol. 2012; 30:2039–2045.
3. Pfisterer J, Plante M, Vergote I, du Bois A, Hirte H, Lacave AJ, et al. Gemcitabine plus carboplatin compared with carboplatin in patients with platinum-sensitive recurrent ovarian cancer: an intergroup trial of the AGO-OVAR, the NCIC CTG, and the EORTC GCG. J Clin Oncol. 2006; 24:4699–4707.
4. Parmar MK, Ledermann JA, Colombo N, du Bois A, Delaloye JF, Kristensen GB, et al. Paclitaxel plus platinum-based chemotherapy versus conventional platinum-based chemotherapy in women with relapsed ovarian cancer: the ICON4/AGO-OVAR-2.2 trial. Lancet. 2003; 361:2099–2106.
5. Alberts DS, Liu PY, Wilczynski SP, Clouser MC, Lopez AM, Michelin DP, et al. Randomized trial of pegylated liposomal doxorubicin (PLD) plus carboplatin versus carboplatin in platinum-sensitive (PS) patients with recurrent epithelial ovarian or peritoneal carcinoma after failure of initial platinum-based chemotherapy (Southwest Oncology Group Protocol S0200). Gynecol Oncol. 2008; 108:90–94.
6. Tomao F, Tomao S, Panici PB. Improvement in progression-free survival in OCEANS bevacizumab arm: a critical point of view. J Clin Oncol. 2013; 31:166–167.
7. Sehouli J, Alfaro V, Gonzalez-Martin A. Trabectedin plus pegylated liposomal doxorubicin in the treatment of patients with partially platinum-sensitive ovarian cancer: current evidence and future perspectives. Ann Oncol. 2012; 23:556–562.
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