J Gynecol Oncol.  2014 Oct;25(4):342-348. 10.3802/jgo.2014.25.4.342.

Completeness of pedigree and family cancer history for ovarian cancer patients

• Son Y
• Lim MC
• Seo SS
• Kang S
• Park SY

• KMID: 2130124
• DOI: http://doi.org/10.3802/jgo.2014.25.4.342

Abstract

OBJECTIVE
To investigate the completeness of pedigree and of number of pedigree analysis to know the acceptable familial history in Korean women with ovarian cancer.
METHODS
Interview was conducted in 50 ovarian cancer patients for obtaining familial history three times over the 6 weeks. The completeness of pedigree is estimated in terms of familial history of disease (cancer), health status (health living, disease and death), and onset age of disease and death.
RESULTS
The completion of pedigree was 79.3, 85.1, and 85.6% at the 1st, 2nd, and 3rd time of interview and the time for pedigree analysis was 34.3, 10.8, and 3.1 minutes, respectively. The factors limiting pedigree analysis were as follows: out of contact with their relatives (38%), no living ancestors who know the family history (34%), dispersed family member because of the Korean War (16%), unknown cause of death (12%), reluctance to ask medical history of relatives (10%), and concealing their ovarian cancer (10%). The percentage of cancers revealed in 1st (2%) and 2nd degree (8%) relatives were increasing through surveys, especially colorectal cancer related with Lynch syndrome (4%).
CONCLUSION
Analysis of pedigree at least two times is acceptable in Korean woman with ovarian cancer from the first study. The completion of pedigree is increasing, while time to take family history is decreasing during three time survey.

Keyword

Completeness; Family history; Lynch syndrome; Ovarian cancer; Pedigree

MeSH Terms

Adult
Age Distribution
Age of Onset
Aged
Colorectal Neoplasms, Hereditary Nonpolyposis/genetics
Cross-Sectional Studies
Female
Genetic Predisposition to Disease
Humans
Medical History Taking/*methods
Middle Aged
Neoplasm Staging
Ovarian Neoplasms/*genetics/pathology
Pedigree
Young Adult

Figure

• 

  Fig. 1 Completeness of pedigree and time to obtain family history.

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