J Korean Acad Nurs.  2014 Oct;44(5):542-551. 10.4040/jkan.2014.44.5.542.

Incidence and Factors Influencing Oral Mucositis in Patients with Hematopoietic Stem Cell Transplantation

• Jo KS
• Kim NC

• KMID: 2129544
• DOI: http://doi.org/10.4040/jkan.2014.44.5.542

Abstract

PURPOSE
This study was done to examine the incidence of oral mucositis in hematopoietic stem cell transplantation patients and to identify factors influencing oral mucositis and patient outcomes according to severity.
METHODS
In this retrospective study, data were collected from electronic medical records of 222 patients who had received hematopoietic stem cell transplantation. Oral mucositis was evaluated using WHO's assessment scale. Data were analyzed using Chi-square test, Fisher exact test, Spearman's correlation, Ordinal logistic regression, ANOVA and Kruskal-Wallis test.
RESULTS
A total of 69.8% of the patients evaluated developed oral mucositis (grade II and over). As a results of ordinal regression, factors influencing oral mucositis severity were found to be diagnosis, type of transplantation, oxygen inhalation and the number of antiemetics administration before transplantation. The severity of oral mucositis was found to increase the days of hospitalization, days of TPN administration, days of using antibiotics and the number and dosage of analgesics.
CONCLUSION
The results would help predict severity of oral mucositis in hematopoietic stem cell transplantation patients and suggest that provision of appropriate nursing assessment and oral care would improve patient outcomes.

Keyword

Hematopoietic stem cells; Transplantation; Mucositis

MeSH Terms

Adolescent
Adult
Analgesics/therapeutic use
Anti-Bacterial Agents/therapeutic use
Body Mass Index
Female
*Hematopoietic Stem Cell Transplantation
Hospitalization
Humans
Incidence
Length of Stay
Leukemia/therapy
Logistic Models
Male
Middle Aged
Oxygen Inhalation Therapy
Parenteral Nutrition, Total
Radiation Dosage
Retrospective Studies
Severity of Illness Index
Stomatitis/*epidemiology/pathology/prevention & control
Young Adult
Analgesics
Anti-Bacterial Agents

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