Tuberc Respir Dis.
1995 Oct;42(5):752-759. 10.4046/trd.1995.42.5.752.
Bronchial Responsiveness in Patients with Mitral Valvular Heart Disease
- Affiliations
-
- 1Department of Internal Medicine, School of Medicine Gyeongsang National University, Chinju, Korea.
- KMID: 2128555
- DOI: http://doi.org/10.4046/trd.1995.42.5.752
Abstract
- BACKGROUND
Bronchial asthma is characterized by noctunal dyspnea, cough and wheezing because of airway hyperresponsiveness to nonspecific stimuli. These symptoms and signs are also observed in patients with congestive heart failure. Therefore, this is so called "cardiac asthma". There are lots of experimental and clinical datas to suggest that airway dysfunctions occur in acute and chronic congestive heart failure. However, it is still controversial whether bronchial hyperresponsiveness is present in patients with congestive heart failure. To assess whether bronchial hyperresponsiveness is present in patients with congestive heart failure and to demonstrate the relationship between bronchial responsiveness and vascular pressure, we performed methacholine provocation test in 11 patients with mitral valvular heart disease.
METHODS
All patients were in the New York Heart Association functional class II and treated continuously with digoxin and/or dichlozid and/or angiotensin converting enzyme inhibitor except one patient. All patients were undergone right and left side heart catheterization for hemodynamic measurements. A 20 percent fall of peak expiratory flow rate were considered as positive response to methacholine provocation test.
RESULTS
1) Only one patient who has normal pulmonary artery pressure, pulmonary capillary wedge pressure, cardiac index was positive in methacholine provocation test. 2) Their mean pulmonary artery pressure, pulmonary capillary wedge pressure were 21.72 +/- 9.70mmHg, 15.45 +/-8.69mmHg respectively which were significantly higher.
CONCLUSION
It is speculated that in stable congestive heart failure patients, bronchial responsiveness as assessed by methacholine provocation test may not be increased.
