J Korean Ophthalmol Soc.  1996 Aug;37(8):1270-1276.

The Effect of Corticosteoid Treatment on Myopic Regression after Photorefractive Keratectomy

• Woo KH
• Kim KS

Abstract

With the aim of reversing myopic regression after PRK, the effect of highdose topical corticosteroid in modulating changes in refraction and corneal transparency were assessed prospectively. Seventy-two eyes of 62 patients (mean preoperative SE -6.14D; -2.30 D to -11.50D), demonstrating myopic regression ranging between -0.75D to -5.33D (mean: -1.69D), were treated with 0.1% dexamethasone eye solution five times a day for averaging 2.8 weeks. The age of patient, amount of attempted correction and K-reading did not influenced statistically significantly on myopic regression. Uncorrected visual acuity, mean refraction before reintroducing corticosteroids (mean: 0.58, -1.69D) improved after corticosteroid treatment (mean: 0.85, -0.42D)(p<0.01). Corneal haze changed statistically significant from 0.80 +/- 0.61 to 0.53 +/- 0.40 after steroid treatment(p<0.01). Topical corticosteroid therapy can modulate refractive changes after PRK, appearing to improve myopic regression. However, a long term follow up will be necessary to determine the final refractive outcome of these eyes.

Keyword

Excimer laser; Myopic regression; Photorefractive keratectomy; Corticosteroid

MeSH Terms

Adrenal Cortex Hormones
Dexamethasone
Follow-Up Studies
Humans
Lasers, Excimer
Photorefractive Keratectomy*
Prospective Studies
Visual Acuity
Adrenal Cortex Hormones
Dexamethasone