J Korean Ophthalmol Soc.  1975 Dec;16(4):327-330.

Experimental Studies on the Release of 17-Hydroxycorticosteroids from Soaked Soft Contact Lenses

• Cho HW
• Youn DH

Abstract

The therapeutic application of the soft contact lenses are popular in ophthalmic use recently. Drug effects of greater magnitude and duration may be achieved by using a soft contact lens soaked with drugs. Using mycon-soft lenses, with different diameter (14.5mm, 12.0mm) and thickness (0.2mm, 0.1mm), soaked in 2.5% hydrocortisone acetate or 2.5% hydrocortisone succinate for 15 minutes and 30 minutes according to the protocol, and elution studies were performed. Elution rate were not influenced by the thickness of contact lens and soaked time in drugs, but it was influenced by the size of contact lens. It showed that increased elution rate in larger contact lens than smaller one. It was suggested that neither hydrocortisone acetate nor hydrocortisone succinate were absorbed by the soft contact lens but were adhered to the lens surface and released from it gradually.

MeSH Terms

17-Hydroxycorticosteroids*
Contact Lenses, Hydrophilic*
Hydrocortisone
Succinic Acid
17-Hydroxycorticosteroids
Hydrocortisone
Succinic Acid