J Korean Radiol Soc.
1995 Dec;33(6):945-948.
Chemical Dissolution of Intrahepatic Stones in Vitro
Abstract
- PURPOSE
The in vitro dissolution of intrahepatic stones was evaluated using the various solvent mixtures.
MATERIALS AND METHODS
Sixty four intrahepatic stones from 16 patients were used. Four kinds of solvent mixtures(No. 1 = basic buffer + EDTA, No. 2=1 + Sulfobetain-12, No. 3=2 + N-acetylcysteine, No. 4=3 + urea) were used. Dissolution rates were determined by measuring the weight loss of stones after 6, 12, 24, 48 hours incubation periods, respectively.
RESULTS
The highest dissolution rates in dissolving intrahepatic stones were achieved with No. 4 solvent mixture(1% W/V EDTA/80mM, Sulfobetain-12/1 M, urea, pH 9.5).
CONCLUSION
lntrahepatic stones could be largely dissolved up to about 70% of their initial weight after 48 hours incubation period in vitro.
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