Atypical Syringocystadenoma Papilliferum with Adenomatous Hyperplasia

Hwang, Sang Min; Choi, Eung Ho; Lee, Won Soo; Ahn, Sung Ku

Abstract

We report a case of syringocystadenoma papilliferum (SCAP) occurring in a 28 year-old male who had a 2cm X 1cm X0.7cm sized papillomatous and cauliflower-like tumor on the left inguinal area without any subjective symptoms. A Histopathological examination revealed cystic invaginations which contained a few well defined papillary projections and proliferation of ductal structures at the periphery. The papillae were covered by columnar epithelial cells on the luminal side with frequent, tufting and piling up, whereas the underlying cells were small cuboidal ones and contained a vascularized stroma and dense lymphoplasma cell infiltration. The majority of ductules contained amorphous eosinophilic material and some showed intraluminal papillation and decapitation secretion. Immunohistochemical studies with S-100 antigen, CEA, and EMA were performed. Studies of S-100 antigen and EMA were nonspecific. CEA was positive in the amorphous intraluminal materials and apical cells of the lumen. The histopathological and immunohistochemical studies revealed rather typical findings of SCAP.