J Korean Orthop Assoc.  2008 Apr;43(2):247-251. 10.4055/jkoa.2008.43.2.247.

Aberrant Chromosomal Alterations in Bizarre Parosteal Osteochondromatous Proliferation (Nora's Lesion) of Hand: A Case Report

• Kim KJ
• Kim HY
• Yang DS
• Choy WS
• Ihm CW

• KMID: 2106447
• DOI: http://doi.org/10.4055/jkoa.2008.43.2.247

Abstract

Bizarre parosteal osteochondromatous proliferation is a disease similar to an osteochondroma that usually involves the metatarsal, metacarpal, proximal and middle phalanx. The symptoms are normally caused by the bone mass, the condition has a benign clinical course but recurrence is common. Recently, it was reported that there is a translocation between chromosome 1 and 17. We report a case of BPOP in the middle phalanx of hand with translocations and duplication in cytogenetic karyotyping with a review of relevant literature.

Keyword

Hand; Bizarre parosteal osteochondromatous proliferation; Cytogenetic karyotyping

MeSH Terms

Chromosomes, Human, Pair 1
Cytogenetics
Hand
Karyotyping
Metatarsal Bones
Osteochondroma
Recurrence

Figure

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  Fig. 1 Photographs showing a dorsoulnar bony mass located in the middle phalanx of the 4th finger.

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  Fig. 2 Preoperative radiographs showing a 7×7 mm sized exostotic mass on the dorsoulnar aspect middle phalanx of the 4th finger. The protruding bony mass does not connect with the medullary cavity of middle phalanx.

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  Fig. 3 Computed tomography scans showing an irregular and calcified mass of the middle phalanx.

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  Fig. 4 Intraoperative photograph showing a whitish and irregular calcified mass.

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  Fig. 5 Photomicrograph showing a bizarre chondrocyte, osteoid and spindle cells that favor bizarre parosteal osteochondromatous proliferation (BPOP).

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  Fig. 6 Cytogenetic karyotyping showing t(3;17)(p21;p13), t(7;15)(q32;q15) and dup(15)(q15;q22).

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  Fig. 7 Postoperative 12 months radiographs showing no evidence of local recurrence.

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