J Korean Pediatr Soc.
2003 Mar;46(3):224-229.
Maternal and Neonatal Outcome of Twin Pregnancies after in vitro Fertilization and Embryo Transfer
- Affiliations
-
- 1Department of Pediatrics, Samsung Jeil Hospital, College of Medicine, Sungkyunkwan University, Korea. arkim@amc.seoul.kr
- 2Division of Neonatology, Department of Obstetric and Gynecology, Asan Medical Center, College of Medicine, Ulsan University, Seoul, Korea.
- 3Division of Neonatology, Department of Pediatrics, Asan Medical Center, College of Medicine, Ulsan University, Seoul, Korea.
Abstract
- PURPOSE
To examine various neonatal outcomes and perinatal factors resulting from assisted reproduction compared to that of spontaneous conception.
METHODS
This is a retrospective study. The control cases were all twins of spontaneous conception born between periods from January 1995 to June 2000. The study cases were identified from twins conceived by assisted reproduction in the same time peried. A total of 460 sets of twins consisted of 250 twins of spontaneous conception and 156 twins of assisted reproduction were studied. The primary outcomes were neonatal morbidity and mortality and the secondary outcomes were perinatal factors including number, length and cost of hospitalization for the delivery.
RESULTS
No differences were seen in various neontal factors including gestational age, birth weight and incidences of respiratory distress syndrome, patent ductus arteriosus, necrotizing enterocolitis, hyperbilirubinemia, sepsis, intraventricular hemorrhage and the length of hospitalizations. Lower one minute and five minute Apgar scores and frequently encountered electrolyte abnormalities were observed in neonates of assisted reproduction. In general, the second twin of assisted reproduction had increased incidences of respiratory distress syndrome, sepsis and necrotizing enterocolitis than the first twin. Increased frequencies of preterm labor, hospitalization and elective cesarean section were seen among mothers who underwent artifical conception. However, overall hospital costs in terms of mothers hospitalization for the delivery and neonates hospitalization did not show differences.
CONCLUSION
Assisted reproduction twins had similar neonatal morbidities, mortalities and perinatal morbidities compared to those born by spontaneous conception.
MeSH Terms
-
Birth Weight
Cesarean Section
Ductus Arteriosus, Patent
Embryo Transfer*
Embryonic Structures*
Enterocolitis, Necrotizing
Female
Fertilization
Fertilization in Vitro*
Gestational Age
Hemorrhage
Hospital Costs
Hospitalization
Humans
Hyperbilirubinemia
Incidence
Infant, Newborn
Mortality
Mothers
Obstetric Labor, Premature
Pregnancy
Pregnancy, Twin*
Reproduction
Retrospective Studies
Sepsis
Systemic Inflammatory Response Syndrome
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