J Korean Radiol Soc.  1998 Jan;38(1):175-179. 10.3348/jkrs.1998.38.1.175.

MR Imaging of Osteosarcoma after Intraarterial Chemotheraphy: Importance of Gd-DTPA Enhancement

• Baek KH
• Huh JD
• Oh KS
• Jung GS
• Joh YD

• KMID: 2103071
• DOI: http://doi.org/10.3348/jkrs.1998.38.1.175

Abstract

PURPOSE: To review MRI in order to compare Gd-DTPA enhanced images before and after preoperative intraarterialchemotherapy for osteosarcoma.
MATERIALS AND METHODS
In sixteen patients with pathologically-proven osteosarcomawho underwent intra-arterial chemotherapy, MR images were obtained before and after this treatment. The degree[grade 0(low) to IV(high)] and pattern (homogenous, inhomogenous) of changes in contrast enhancement and tumorsize were evaluated.
RESULTS
Enhancement changed from Grade III to I in eight patients and from Grade III to IIin five. In three, the enhancement pattern changed from homogenous to inhomogenous; in ten, the inhomogenouspattern did not change; and in three, there was a change from thick, irregular to thin, smooth-rimmed enhancement.In all patients except one, the intraosseous tumor component was not changed. The extraosseous component becamelarger in three patients, smaller in two, and showed no size change in eleven.
CONCLUSION
In osteosarcoma, MRimaging after Gd-enhancement following intra-arterial chemotherapy showed decresased enhancement, and increasedinhomogeneity and smooth rim enhancement. Neither the intra-nor extraosseous tumor component showed size changewith time.

Keyword

Extremities, neoplasms; Bone neoplasm, MR; Osteosarcoma

MeSH Terms

Drug Therapy
Gadolinium DTPA*
Humans
Magnetic Resonance Imaging*
Osteosarcoma*
Gadolinium DTPA