J Korean Soc Clin Toxicol.  2011 Dec;9(2):88-94.

Factors Associated with Delayed Neuropsychological Sequelae in Acute Carbon Monoxide Poisoning Patients Treated by Hyperbaric Oxygen

• Lee DH
• Choi WI

Abstract

PURPOSE
Delayed neuropsychological sequelae (DNS) commonly occurs after recovery from acute carbon monoxide poisoning. The aim of this article is to identify the factors associated with DNS development.
METHODS
We retrospectively evaluated patients, admitted to the medical center emergency department from June 2005 to March 2011, who were suffering from acute carbon monoxide (CO) poisoning. We categorized the patients into two groups - those with DNS, and those without DNS. Multiple regression analysis was performed to identify the factors related to manifestation of DNS.
RESULTS
Of the total one hundred fifty seven patients (157) recruited for the study, twenty two (22) developed DNS. Longer CO exposure times and lower GCS scores were positively associated with development of DNS symptoms.
CONCLUSION
Our study identified two potential factors which are predictive of DNS development in CO intoxication, however, more studies are needed. Adequate follow-up after hospital discharge to monitor for and accurately identify manifestation of DNS, is also important.

Keyword

Carbon monoxide; Neuropsychology; Sequelae

MeSH Terms

Carbon
Carbon Monoxide
Carbon Monoxide Poisoning
Emergencies
Follow-Up Studies
Humans
Neuropsychology
Organothiophosphorus Compounds
Oxygen
Retrospective Studies
Stress, Psychological
Carbon
Carbon Monoxide
Organothiophosphorus Compounds
Oxygen