J Korean Soc Neonatol.  2005 May;12(1):63-69.

The Risk Factors of Cholestasis in Very Low Birth Weight Infants

• Jeon GW
• Choi CW
• Hwang JH
• Gu SH
• Kim YJ
• Lee JH
• Chang YS
• Park WS

Abstract

PURPOSE
This study was aimed to investigate the risk factors of cholestasis in very low birth weight infants (VLBWI). METHODS: The study includes 466 VLBWI admitted to the neonatal intensive care unit at Samsung medical center from November 1994 to January 2003 and the data were collected retrospectively from their medical records. They were divided into two groups; cholestatic group (group 1) and control group (group 2) by level of direct bilirubin at 2.0 mg/dL. RESULTS: The mean gestational age and birth weight were lower in group 1. In group 1, enteral feeding was started later, time to achieve full and near full enteral feeding were delayed and duration of parenteral nutrition was longer than group 2. The incidence of bronchopulmonary dysplasia was significantly higher in group 1, but the incidences of sepsis and necrotizing enterocolitis were not different between the two groups. After adjusting for birth weight and gestational age, logistic regression analysis of the above factors revealed that the factors significantly related to cholestasis were longer duration of parenteral nutrition and longer time to achieve near full enteral feeding. CONCLUSION: Earlier near full enteral feeding and shorter duration of parenteral nutrition decreased the incidence of cholestasis.

Keyword

Cholestasis; Very low birth weight infant; Enteral feeding; Total parenteral nutrition

MeSH Terms

Bilirubin
Birth Weight
Bronchopulmonary Dysplasia
Cholestasis*
Enteral Nutrition
Enterocolitis, Necrotizing
Gestational Age
Humans
Incidence
Infant*
Infant, Newborn
Infant, Very Low Birth Weight*
Intensive Care, Neonatal
Logistic Models
Medical Records
Parenteral Nutrition
Parenteral Nutrition, Total
Retrospective Studies
Risk Factors*
Sepsis
Bilirubin