J Korean Soc Pediatr Nephrol.
2004 Oct;8(2):250-255.
Early Onset of Minimal change Nephrotic Syndrome during Treatment with D-penicillamine in a Patient with Wilson s Disease
- Affiliations
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- 1Departments of Pediatrics, College of Medicine, Konyang University, Taejon, Korea. kcm1000@kyuh.co.kr
- 2Departments of Pathology, College of Medicine, Konyang University, Taejon, Korea.
Abstract
- Wilson s disease is an autosomal recessive disorder characterized by degenerative changes in the brain, liver, and cornea. Treatment includes D-penicillamine, trientine, and zinc sulfate. D-penicillamine has been used frequently as first line therapy for Wilson s disease. However, nephrotoxicity can occur after D-penicillamine treatment. Among them membranous glomerulopathy is the most common histological abnormality but minimal change lesions have also been reported. Nephrotic syndrome is a late complication of D-penicillamine treatment but very rarely can occur within 2 months after treatment of D-penicillamine. We report the early development of minimal change nephrotic syndrome in a 3-year-old girl with Wilson s disease 3 weeks after initiation of D-penicillamine.
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