J Korean Soc Ther Radiol.  1993 Dec;11(2):277-284.

Induction Chemotherapy Plus Radiation Compared with Surgery Plus Radiation in Patients with Advanced Laryngeal and Hypopharyngeal Cancer

• Keum KC
• Lee CG
• Kim GE
• Lee KH

Abstract

BACKGROUND: We performed a retrospective study in patients with previously untreated advanced(Stage III or IV) laryngeal and hypopharyngeal cancer to compare the results of induction chemotherapy followed by definitive radiation therapy (CT+RT) with those of conventional laryngectomy and postoperative radiation therapy (OP+RT). METHOD: Between 1985 and 1990, twenty four patients were treated with two or three courses of chemotherapy and radiation therapy(66~75 Gy). Twenty-five patients were received laryngectomy and radical neck dissection(except 3 patients) and postoperative radiation therapy (55~04 Gy). RESULT: After a median follow-up of 20 months, the actuarial 5-year overall survival rate was 24% (chemotherapy group) and 36% (op group).(P>0.1). The local control rate was the 65%,(13/20) and 68.2%(15/22).(P>0.1). The rate of laryngeal preservation was 65%(13/20) in chemotherapy group.
CONCLUSION
Induction chemotherapy and definitive radiation therapy can be effective in preserving the larynx in a high percentage of patients with advanced laryngeal and hypopharyngeal cancer.

Keyword

Induction chemotherapy; Radiotherapy; Laryngeal and hypopharyngeal cancer

MeSH Terms

Drug Therapy
Follow-Up Studies
Humans
Hypopharyngeal Neoplasms*
Induction Chemotherapy*
Laryngectomy
Larynx
Neck
Radiotherapy
Retrospective Studies
Survival Rate