J Korean Soc Ther Radiol.  1992 Jun;10(1):49-58.

External Radiation Therapy Combined with Hyperthermia in the Carcinoma of Extrahepatic Biliary System

• Bae HS

Abstract

From January 198e to September 1990,7 patients with carcinoma of the extrahepatic biliary system received external radiaiton therapy combined with hyperthermia. of the 3 patients with extrahepatic bile duct cancer, two were primary cholangiocarcinoma and one was metastatic peripancreatic carcinoma. Of the 4 patients with carcinoma of the gallbladder, two were locoregionally advanced and unresectable carcinoma and the remaining two were local-regional recurrence after cholecystectomy. They were all pathologicallly proven adenocarcinoma. The radiation dose received ranged from 3000 cGy/2weeks to 5040 cGy/ 7weeks. The hyperthermia was done once or twice a week and 4 to 12 sessions in total. The tumor response was confirmed by T-tube cholangiography, percutaneous transhepatic cholangiography and CT scan. 6 out of 7(86%) showed partial regression of the tumor. The median survival time was 7 months (range 4~11 Months). 6 out of 7 patients were dead : one died of septicemia, 4 of primary disease, one of distant metastases. Only one out of 7 patients is still alive but new metastatic lesion was found. There was not any treatment related deaths. There was also no evidence of treatment related problems with liver, stomach and duodenum, although the observation period was short.

Keyword

Bile duct cancer; Gallbladder cancer; Radiotherapy; Hyperthermia

MeSH Terms

Adenocarcinoma
Bile Duct Neoplasms
Bile Ducts, Extrahepatic*
Cholangiocarcinoma
Cholangiography
Cholecystectomy
Duodenum
Fever*
Gallbladder
Gallbladder Neoplasms
Humans
Liver
Neoplasm Metastasis
Radiotherapy
Recurrence
Sepsis
Stomach
Tomography, X-Ray Computed