Ann Surg Treat Res.  2015 Nov;89(5):254-260. 10.4174/astr.2015.89.5.254.

Effect of extramucin pools in gastric cancer patients

• Kim KH
• Lee SH
• Choi CW
• Kim SJ
• Choi CI
• Kim DH
• Jeon TY
• Kim DH
• Hwang SH

• KMID: 2095531
• DOI: http://doi.org/10.4174/astr.2015.89.5.254

Abstract

PURPOSE
Mucinous gastric adenocarcinoma (MGC) is defined by the World Health Organization as a gastric adenocarcinoma with >50% extracellular mucin pools within the tumors. In this study, we attempted to analyze the clinicopathologic features of patients pathologically diagnosed as gastric cancer with lower than 50% tumor volume of extracellular mucin pool adenocarcinoma (LEMPC). We compared MGC versus nonmucinous gastric adenocarcinoma (NMGC). We were used in abbreviations LEMPC for NMGC including extracellular mucin pool.
METHODS
Files of 995 patients with gastric cancer NMGC (n = 935), MGC (n = 20), LEMPC (n = 40) who underwent curative resection at Pusan National University Yangsan Hospital from December 2008 to December 2013 were retrospectively analyzed. All pathologic reports after curative resection and evaluated clinicopathologic features were reviewed to identify the effect of extracellular mucin pools in gastric cancer.
RESULTS
Compared with the NMGC patients, the clinicopathological features of MGC patients were as follows: more frequent open surgery, larger tumor size, more advanced T stage and N stage, more positive lymph node metastasis, and perineural invasion. LEMPC patients showed similar features compared with NMGC patients. MGC and LEMPC patients showed similar clinicopathological features, except T stage and lymph node metastasis.
CONCLUSION
LEMPC can be thought of as a previous step of MGC. It is reasonable to consider LEMPC patients in the diagnostic criteria of MGC, and to adequately treat.

Keyword

Mucinous adenocarcinoma; Stomach; Neoplasms

MeSH Terms

Abbreviations
Adenocarcinoma
Adenocarcinoma, Mucinous
Busan
Gyeongsangnam-do
Humans
Lymph Nodes
Mucins
Neoplasm Metastasis
Retrospective Studies
Stomach
Stomach Neoplasms*
Tumor Burden
World Health Organization
Mucins

Figure

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  Fig. 1 Extracellular mucin pools are lower than one half of the tumor area (A, Hematoxylin and eosin stain ×20) and mucinous gastric adenocarcinoma (B, Hematoxylin and eosin stain).

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  Fig. 2 Flow chart of the study. NMGC, nonmucinous gastric adenocarcinoma; MGC, mucinous gastric adenocarcinoma; LEMPC, gastric cancer with <50% tumor volume of extra-cellular mucin pool carcinoma.

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  Fig. 3 Disease-free survival curves using the Kaplan-Meier method for gastric cancers diagnosed NMGC and all extracelluarmucin pool gastric carcinoma. NMGC, nonmucinous gastric adenocarcinoma; LEMPC, gastric cancer with <50% tumor volume of extracellular mucin pool adenocarcinoma; MGC, mucinous gastric adenocarcinoma.

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