Korean Circ J.  2001 May;31(5):492-499. 10.4070/kcj.2001.31.5.492.

The Rescue Use of A Platelet Glycoprotein IIb/IIIa Receptor Blocker (Abciximab; Reo-Pro ) in High-Risk Patients with Acute Myocardial Infarction Underwent Percutaneous Coronary Intervention

• Kim W
• Jeong MH
• Kim KH
• Park JC
• Lee SH
• Rhew JY
• Kang KT
• Kim NH
• Kim KH
• Ahn YK
• Cho JG
• Park JC

• KMID: 2093812
• DOI: http://doi.org/10.4070/kcj.2001.31.5.492

Abstract

BACKGRUOND: Platelets are known to play a major role in the ischemic complications of percutaneous coronary intervention (PCI). Accordingly, we evaluated the effect of rescue use of a platelet glycoprotein IIb/IIIa receptor blocker (Abciximab; Reo-Pro ) in Korean patients with acute myocardial infarction (AMI) at high risk for the ischemic complications who underwent PCI. METHOD: Sixty eight patients (54 male, 59.1+/-9.96 years) treated by the rescue use of Reo-Pro out of 1,117 patients underwent PCI at Chonnam National University Hospital from Mar 1999 to Feb 2000. All of target lesions were thrombus-containing lesions in patients with AMI. The primary end points consisted of any of the followings : cardiac death, nonfatal MI, repeated revascularization. The number of end-point events were tabulated at 6 months after PCI.
RESULTS
The primary success rate was 92.6% (63/68). At primary end points, there were 5 cases (7.3%), composed of 2 deaths (2.9%), 1 MI, 2 repeated revascularization (2.9%). There was no major bleeding complication after PCI. At secondary end point, there were 23 cases (34.9%) including primary end point, composed of 3 deaths (4.4%), 1 MI and 19 revascularization (28.0%).
CONCLUSION
The rescue Reo-Pro can be used safely and effectively in high-risk Korean patients with AMI.

MeSH Terms

Blood Platelets*
Death
Glycoproteins*
Hemorrhage
Humans
Jeollanam-do
Male
Myocardial Infarction*
Percutaneous Coronary Intervention*
Glycoproteins