Korean Circ J.  1987 Sep;17(3):401-409. 10.4070/kcj.1987.17.3.401.

Assessment of Left Ventricular Diastolic Function in Mild to Moderate Hypertension by Radionuclide Ventriculography

• Jeong MH
• Park SJ
• Kim SG
• Park JC
• Kang JC
• Park OK
• Bom HS
• Kim JY

• KMID: 2093207
• DOI: http://doi.org/10.4070/kcj.1987.17.3.401

Abstract

To determine whether are significant diastolic left ventricular dysfunctions in mild to moderate hypertensive patients with normal systolic function, radionuclide ventriculography by in vivo red cell labelling technique using 20 mCi of (99m)Tc pertechnetate was performed in 24 hypertensive patients(mean age: 50.6+/-12.4, mean blood pressure: 156.9+/-11.8/100.6+/-7.1 mmHg) and in 11 normal subjects (mean age: 42.7+/-13.5, mean blood pressure: 123.2+/-6.8/82.3+/-3.9 mmHg). The results were as follows: 1) Ejection fraction was similar in both hypertensive and control groups (0.70+/-0.06 versus 0.70+/-0.08). 2) Mean of the peak filling rate (PFR) was significantly lower in hypertensive group (2.07+/-0.45 EDV/sec) than in control group (2.42+/-0.30 EDV/sec) (p<0.05). 3) Mean of the time to peak diastolic filling (TPDF) in hypertensive patients was 189.0+/-30.4 msec and which was significantly longer than that of control subjects (164.5+/-22.4 msec)(p<0.02). 4) Mean of the first third filling fraction (1/3 FF) in hypertensive patients was 0.22+/-0.07 and which was significantly lower than that of control subjects (0.32+/-0.09)(p<0.01). 5) Decreased PFR and delayed TPDF were also demonstrated with advances in age in both groups. Above results suggest that the diastolic evaluation of left ventricle might be necessary in the hypertensive patients with normal systolic function, and that diastolic dysfunction may precede the systolic dysfunction and clinical deterioration.

MeSH Terms

Blood Pressure
Heart Ventricles
Humans
Hypertension*
Radionuclide Ventriculography*
Sodium Pertechnetate Tc 99m
Ventricular Dysfunction, Left
Sodium Pertechnetate Tc 99m