Korean Circ J.  1983 Dec;13(2):403-407. 10.4070/kcj.1983.13.2.403.

Antihypertensive Effect of Long-acting Propranolol(Inderal LA(R)) A Clinical study

• Kang JC
• Jeong JW
• Ahn YA
• Kim HJ
• Lee CS
• Park KO
• Park OK

• KMID: 2093169
• DOI: http://doi.org/10.4070/kcj.1983.13.2.403

Abstract

A clinical study on the antihypertensive effect of long-acting propranolol was performed in 25 patients with essential hypertension. Following a week treatment of the subjects with the regimen of propranolol 40mg twice a day during the first week, 160mg of long-acting propranolol was given once a day for the subsequent 4 weeks. At the end of the fifth week, in 8 out of 25(32%) blood pressures were lowered to the level of 140/90 mmHg or lower, in another 8(32%) the blood pressures were lowered by 20 mmHg or more of systolic and/or 10mmhg or more of the diastolic pressures. Eleven out of 12 subjects, whose blood pressures had been significantly lowered at the end of the first week of propranolol treatment, manifested significant blood pressure lowerings also at the end of 4 weeks' long-acting propranolol treatments. Long-acting propranolol had beneficial effect of ameliorating anginal pain in 2 subjects who had had angina pectoris before the beginning of hypertension. Adverse side eiffects observed were mild fatigue in one, indigestion in one and sinus bradycardia in another one.

MeSH Terms

Angina Pectoris
Blood Pressure
Bradycardia
Dyspepsia
Fatigue
Humans
Hypertension
Propranolol
Propranolol