Korean Circ J.
1983 Dec;13(2):395-401. 10.4070/kcj.1983.13.2.395.
Effect of Atenolol on Left Ventricular Function in Essential Hypertension
- KMID: 2093168
- DOI: http://doi.org/10.4070/kcj.1983.13.2.395
Abstract
- This study was made to evaluate the effect of oral atenolol, a cardioselective beta-adrenergic blocking agent without intrinsic sympathomimetic activity, on left ventricular function in patient with essential hypertension. Atenolol, 100mg/day, was given to 11 hypertensive patients for 4 weeks, and its effects on arterial pressure, pulse rate, left ventricular dimensions and ejection phase indices of myocardial performance were examined by echocardiography. Echocardiographic studies were performed before treatment and after 4 weeks of atenolol therapy. Arterial pressure fell form 145/90 mmHg to 138/84mmHg after 4 weeks. Pulse rate fell significantly from 69/min to 58/min(p<0.05). Left ventricular end-diastolic and end-systolic dimensions and mean rate of circumferential fiber shortening(mVcf) did not change significantly. Ejection fraction increased significantly from 0.66 to 0.72(p=0.01). This results indicate that atenolol in the resting state has no depressant effect on left ventricular function in patients with essential hypertension.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Hypotensive Effect of Cardioselective Beta-Blockade with Once-Daily Atenolol Therapy in Essential Hypertension
- Left ventricular hypertrophy and diastolic function in children and adolescents with essential hypertension
- Relation of hemodynamic load to left ventricular hypertrophy and performance in essential hypertension
- Clinical Observation on Antihypertensive Effect of Nicardipine Hydrochloride(Perdipine(R))
- A Study on Left Ventricular Mass in Patients with Hypertension
