Korean J Anesthesiol.  1998 Oct;35(4):738-744. 10.4097/kjae.1998.35.4.738.

Hemodynamic Changes during Continuous Hyperthermic Intraperitoneal Perfusion for Gastric Cancer Patients with Peritoneal Seeding

• Lee YM
• Baek CH
• Chung SL

• KMID: 2091295
• DOI: http://doi.org/10.4097/kjae.1998.35.4.738

Abstract

BACKGREOUND: Hyperthermia is currently effective treatment against numerous cancer gastric cells' seeding on the peritoneal surface and floating in the cancerous ascites. We evaluated changes in hemodynamics during continuous hyperthermic intraperitoneal perfusion (CHPP) to determine strategies for safer general management during this procedure.
METHODS
Ten patients with far-advanced gastric cancer were given surgical treatment followed by CHPP with anticancer drug. The body temperature, blood pressure, heart rate, central venous pressure, pulmonary artery pressure, cardiac output, electrolyte and blood gas were measured during pre-CHPP, CHPP and post-CHPP period.
RESULTS
The blood temperature reached 39.3 +/- 0.4 degrees C(mean SD) during CHPP. Heart rate increased to 104.4 +/- 14.2 bpm and the cardiac index to 5.3 +/- 1.5 l.min 1.m 2 during CHPP. The mean arterial pressure remained stable during the study period. The systemic vascular resistance index decreased to 996.7 +/- 324.0 dynes.s.cm 5.m2. The mixed venous oxygen saturation fell during the first part of the CHPP period.
CONCLUSIONS
This study suggest that the CHPP with anticancer drug may be safe in humans, provided that appropriate monitoring, cooling and technical support are applied.

Keyword

Monitoring: hemodynamics; Hyperthermia: intraperitoneal perfusion; Surgery: gastric cancer

MeSH Terms

Arterial Pressure
Ascites
Blood Pressure
Body Temperature
Cardiac Output
Central Venous Pressure
Fever
Heart Rate
Hemodynamics*
Humans
Oxygen
Perfusion*
Pulmonary Artery
Stomach Neoplasms*
Vascular Resistance
Oxygen