Korean J Anesthesiol.  1992 Jun;25(3):468-476. 10.4097/kjae.1992.25.3.468.

Effects of Intra - Pulmonary Arterial Diltiazem on Hypoxic Pulmonary Vasoconstriction in Dogs

• Kim SD
• Kim CS
• Kim HS
• Lim SW

• KMID: 2090703
• DOI: http://doi.org/10.4097/kjae.1992.25.3.468

Abstract

In this study, we evaluated systemic and pulmonary hemodynamic changes with the administration of diltiazem into pulmonary artery in hypoxia(F1O2 0.15)-induced pulmonary vasoconstriction in 7 mongrel dogs. Hypoxic gas induced pulmonary vasoconstriction(HPV) resulted in 23.8% increase of mean pulmonary arterial pressure(PAP) without any changes of pulmonary vascular resistance(PVR). A 200 ug/kg intravenous bolus of diltazem, followed by 10 ug/kg/min(DL)and 15 ug/kg/min(DH) for 20 min, respectively, produced no change in pulmonary arterial pressure. But this was accompanied by increase in PVR and PVR/SVR ration in DL and 20 min after DH. We conclude that diltiazem does not seem to decrease acute hypoxic pulmonary vasoconstrition in dogs and it might not be beneficial drug for this kind of pulmoary hypertension.

Keyword

Hemodynamics; Hypoxic pulmonary vasoconstrictions(HPV); Diltiazem

MeSH Terms

Animals
Arterial Pressure
Diltiazem*
Dogs*
Hemodynamics
Hypertension
Pulmonary Artery
Vasoconstriction*
Diltiazem