An Experimental Study for the Effect of Interrupted(Intermittently-Repeated) versus Continuous Temporary Clipping on the Change of Arterial Wall of Rat

Bae, Jae Sung; Kim, Kwang Myung; Kim, Young Soo; Ko, Yong; Oh, Seong Hoon; Oh, Suck Jun

Abstract

The benefits of the use of temporary clipping for intracerebral aneurysm surgery were proved through many experimental and clinical studies. There are two techniques of temporary clipping which are interrupted and continuous clipping. In the study of cerebral perfusion, interrupted clipping reduced ischemic damage to the brain. However, the comparison of histological changes in the arterial wall between them is not reported yet. Temporary clipping on the iliac artery of 80 rats was performed using Yasargil temporary mini clip. The specimens were divided into two groups; Group I (intermittently repeated clipping for 5 minutes was done 3 times on the same site with resting interval for 5 minutes: total clipping time was 15 minutes) and Group II (continuous clipping for 15 minutes). Under the light microscope, the histological findings were examined in the specimens, which were obtained at each time-interval after clipping (0 hr, 3 hrs, 6 hrs, 12 hrs, 3 days, and 3 months). The histological changes of the arterial wall of rat by two techniques for temporary clipping were observed. Although there is no significant difference between two temporary clippings, there is a trend of milder and more delayed arterial change in intermittently-repeated temporary clipping.