Korean J Clin Pathol.  1998 Jun;18(2):255-258.

Clinical Usefulness of TrepanostikaTM, Enzyme-Linked Immunosorbent Assay for Detection of Treponema pallidum-Specific Antibody

• Kim YA
• Cho DH
• Kim HS

Abstract

BACKGROUND: The TrepanostikaTM is an enzyme-linked immunosorbent assay (ELISA) for the qualitative determination of specific antibody (Ab) to Treponema pallidum. It is important to detect Treponema pallidum-specific Ab to confirm syphilis in patients with positive nontreponemal result or at late latent stage/late stage. Currently various ELISA methods for Treponema pallidum- specific Ab have been developed in addition to widely used treponemal tests such as fluorescent treponemal antibody absorption (FTA-ABS) test or Treponema pallidum hemagglutination (TPHA) test. We evaluated TrepanostikaTM, anti-treponemal ELISA test.
METHODS
The sensitivity and specificity of this ELISA method for detecting Treponema pallidum- specific Ab (TrepanostikaTM) were evaluated and compared with other treponemal tests such as FTA-ABS and TPHA.
RESULTS
The sensitivity and specificity of TrepanostikaTM were 95.7% and 95.8%, respectively. The concordance rate with FTA-ABS was 98.9% (283/286) and 100% (272/272) with TPHA.
CONCLUSIONS
TrepanostikaTM which has similar sensitivity and specificity with FTA-ABS or TPHA could replace the well-known treponemal test such as FTA-ABS or TPHA.

Keyword

Treponema pallidum-specific antibody; Enzyme-linked immunosorbent assay (ELISA); Syphilis

MeSH Terms

Absorption
Enzyme-Linked Immunosorbent Assay*
Hemagglutination
Humans
Sensitivity and Specificity
Syphilis
Treponema pallidum
Treponema*