Korean J Dermatol.  2008 Jan;46(1):117-121.

Wegener's Granulomatosis Presenting as Pyoderma Gangrenosum

• Kim JE
• Ahn HH
• Kye YC
• Kim SN

Abstract

Wegener's granulomatosis (WG) is a systemic disease of unknown origin characterized by necrotizing granulomatous inflammation and vasculitis. Dermatological symptoms occur in up to 50% of cases, mostly in the form of cutaneous vasculitis or pyoderma gangrenosum. A 51-year-old female presented with multiple ulcerative patches and erythematous nodules on both legs. Histopathological findings showed extensive ill-defined granulomatous lesions and necrotizing vasculitis. Lung biopsy findings were consistent with WG. Nasopharyngeal and gastrointestinal involvement developed later. Skin lesions are improving with systemic corticosteroid and cyclophosphamide. We herein report a case of WG presenting as pyoderma gangrenosum-like cutaneous manifestation with other systemic involvements.

Keyword

ANCA; Pyoderma gangrenosum; Wegener's granulomatosis

MeSH Terms

Antibodies, Antineutrophil Cytoplasmic
Biopsy
Cyclophosphamide
Female
Humans
Inflammation
Leg
Lung
Middle Aged
Pyoderma
Pyoderma Gangrenosum
Skin
Ulcer
Vasculitis
Wegener Granulomatosis
Antibodies, Antineutrophil Cytoplasmic
Cyclophosphamide