Korean J Dermatol.
2001 Aug;39(8):921-927.
A Case of Solitary Indeterminate Cell Histiocytoma
- Affiliations
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- 1Department of Dermatology, Kangnam St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. knderma@cmc.cuk.ac.kr
Abstract
- Indeterminate cell histiocytosis is a vary rare disease characterized by the proliferation of indeterminate histiocytes which morphologically and immunophenotypically resemble Langerhans cell but lack Birbeck granules. We report a case of solitary indeterminate cell histiocytoma in a 58-year-old woman. She presented with painless and nonprurituc solitary brownish papule on the left wrist, which had developed 10 years earlier. Histologic and immunohistochemical examination of the biopsy revealed a diffuse dermal infiltrate composed mainly of histiocytes which expressed Langerhans cell marker characteristics. Electron microscopic studies revealed no Birbeck granules within cytoplasm of the neoplastic cells, leading to a diagnosis of indeterminate cell histiocytosis.
