Korean J Dermatol.  1989 Dec;27(6):650-654.

Inflammatory Skin Response to Ultraviolet Radiation: Ear Swelling Response in C57BL Mouse

• Yeo UC
• Kim KH
• Jo MK
• Jeon HP
• Ree JH
• Lee AY
• Youn JI

Abstract

This study was undertaken to investigate the change of ear swelling response (ESR) of the mice according to repetitive ultraviolet radiation. 100mJ/crn of UVB was irradiated daily for 4 weeks, and a total of 25 C57BL mice were used as subjects. The results were as follows : 1. After 1 day, 2 days and 3 days irradiation of UVB, ESR reached 21.3+/-1.5, 22.3+/-1.1 and 24.3+/-1.6 respectively with increasing tendency, but there was no statistical significance (Wilcoxon rank sum test p>0.05). 2. ESR reached at maximum, 78.0+/-1.8, after 1 week(p<0.01), thereafter ESR decreased gradually with reparative process. 3. Inspite of continued irradiation, ESR decreased gradually after 2 weeks. After 2 weeks, 3 weeks and 4 weeks irradiation, ESR decreased to 51.6+/-11.8, 45.1+/- 3.3 and 42.8+/-6.8 respectively, but, there were still increment of ESR (p<0.01).

Keyword

Ear swelling response; UVB; C57BL mouse

MeSH Terms

Animals
Ear*
Mice
Mice, Inbred C57BL*
Skin*