The Effects of Cisapride on Volume of Colonoscopy Lavage Solution

Park, Jeong Ho; Kwon, Jung Hun; Cho, Dae Hyeon; Lee, Hong Sok; Lee, Sung Ho; Kim, Hyun Su; Kim, Hyun Seo; Lee, Hyun Taek; Jang, Jae Kwon; Shim, Sang Goon; Sung, In Kyung; Park, Chan Won

Abstract

BACKGROUND/AIMS
Polyethylene glycol (PEG) electrolyte lavage solution is now commonly used for peroral colonic preparation. However, the need to ingest a large volume reduces patient acceptance and may limit compliance, thereby resulting in improper preparation. This study was designed to assess whether adding of magnesium oxide or cisapride to PEG solution decreased the volume of PEG solution required without compromising the quality of the preparation.
METHODS
One hundred thirty seven patients undergoing outpatient colonoscopy were randomly chosen to receive one of three preparations (Group A: 4 L PEG; Group B: 2 L PEG plus cisapride 20 mg; Group C: 2 L PEG plus magnesium oxide 2 g). Endoscopist was blinded as to the method of preparation and scored the degree of colonic preparation (1 to 4).
RESULTS
Mean scores of preparation in group A, B, and C were 2.85, 2.69, and 2.20, respectively (p=0.001). There were significant differences of the degree of preparation between group A and group C, between group B and group C, but not between group A and group B.
CONCLUSIONS
Two liters of PEG plus cisapride induced equally effective colonic preparation compared to four liter PEG solution. This results show that the addition of cisapride to PEG solution can reduce volume of PEG solution during colonoscopy preparation.