Korean J Gynecol Oncol Colposc.  1992 Mar;3(1):24-29.

Preoperative Serum CA-125 level in Endometrial Carcinoma ; Correlate with Prognostic Variables

• Kim NY
• Ahn CS
• Kim BG
• Song YS
• Kim WH
• Kang SB
• Lee HP

Abstract

We evaluated 2l with endmetrial carcinoma to deterrnine the relationship between the preoperative tumor marker CA-125 level and the postoperative histologic grade and depth of myometrial invasion, from February 1987 to Februaury 199l. In all patients, the clinical stage was I or ~K. In histologic grade, serum CA-l25 level was elevated(>35 U/ml) in 25.0%(2/8) of patients with G l, 20.0%(2/10) of patients with G2, and 33. 3%(1/3) of patients with G3. There was not a significant relationship between elevated serurn CA-l25 level and histologic grade, In depth of myometrial invasion, serum CA-125 leuel was elevated(>35 U/ml) in 6.7%(l/l5) of patients with less than half of the myometrium and 66.7% (4~g6) of patients with more than half of the myometrium. A statistically significant relationship was recorded when the tumor had penetrted rnore than half of the myometrium, Preoperative evaluation of serum CA-125 level could be successfully combmed with other techniques in therapy planning of endometrial careinarna.

MeSH Terms

Animals
Endometrial Neoplasms*
Female
Humans
Mice
Myometrium