Korean J Med.  2009 Apr;76(Suppl 1):S216-S219.

Acute generalized exanthematous pustulosis due to amoxicillin/clavulanate

• Moon SM
• Lee MS
• Son JS

Abstract

Acute generalized exanthematous pustulosis (AGEP) was initially named by Beylot to describe a disease entity with sudden- onset amicrobial pustular eruptions accompanied by fever and leukocytosis. Most cases appear to be related to drug reactions, mainly antibiotics, although viral infections and hypersensitivity to mercury also cause AGEP. A 28-year-old woman presented with sudden-onset, multiple, and generally pinhead-sized pustules on an erythematous base scattered on the face and anterior chest wall. The patient had been on amoxicillin/clavulanate for acute pharyngitis. Histopathologically, the skin biopsy specimen revealed subcorneal and subepidermal pustules with neutrophil spongiosis, perivascular neutrophilic infiltration, and karyorrhectic debris. The eruption cleared rapidly after discontinuing the drug and administering systemic corticosteroid therapy.

Keyword

Acute generalized exanthematous pustulosis; Pustular drug rash; Amoxicillin/clavulanate

MeSH Terms

Acute Generalized Exanthematous Pustulosis
Adult
Anti-Bacterial Agents
Biopsy
Female
Fever
Humans
Hypersensitivity
Leukocytosis
Neutrophils
Pharyngitis
Skin
Thoracic Wall
Anti-Bacterial Agents