Korean J Nephrol.
2010 Nov;29(6):761-767.
Risk Factors for New Onset Diabetes after Transplantation among Renal Transplant Recipients Treated with Tacrolimus
- Affiliations
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- 1Sungkyunkwan University College of Medicine, Division of Nephrology, Samsung Medical Center, Korea. wooseong.huh@samsung.com
- 2Department of Preventive Medicine, Seoul National University College of Medicine, Medical Research Center, Seoul National University, Korea.
- 3Department of Preventive Medicine, Seoul National University College of Medicine, Korea.
Abstract
- PURPOSE
This study was conducted to identify risk factors for new onset diabetes after transplantation (NODAT) among renal transplant recipients treated with tacrolimus-based immunosuppressant.
METHODS
We selected renal transplant recipients who underwent surgery at Samsung Seoul Hospital between May 2001 and July 2009. Exclusion criteria were as follows: recipients <18 years old, history of diabetes mellitus (DM) or impaired glucose tolerance. Analysis of possible risk factors for NODAT included age, gender, body mass index, co-morbid diseases, family history of DM, infection of hepatitis B or polyomavirus, type of donors (cadaver or living) and acute rejection. Overall incidence and median value of NODAT onset day were analyzed with Kaplan-Meier curve. We calculated crude incidence rate and relative risk (RR) and 95% confidence interval (CI) for independent risk factors of NODAT using Cox proportional hazard analysis.
RESULTS
A total of 278 patients were included and the incidence of NODAT was 13.3% (5.6/100 person-year) and the median duration of NODAT onset was 28 days. In Cox analysis, risk factors for NODAT were age (45-59 years: RR=1.41, 95% CI 1.09-1.83, 60> years: RR=4.36, 95% CI 2.00-9.49), family history of DM (RR=1.62, 95% CI 1.12-2.34) and polyomavirus infection (RR=1.40, 95% CI 1.08-1.81).
CONCLUSION
The risk factors for NODAT among renal transplant recipients treated with tacrolimus-based regimen were age (>45 years old), family history of DM and polyomavirus infection.
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