Korean J Nephrol.
2001 Nov;20(6):1058-1063.
A Case of Rheumatoid Arthritis Associated with Renal Amyloidosis and Crescentic Glomerulonephritis
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Ajou University, Suwon, Korea.
- 2Department of Nephrology Pathology, College of Medicine, Ajou University, Suwon, Korea.
Abstract
- A case of renal amyloidosis with crescentic glomerulonephritis associated with rheumatoid arthritis is described. A 60-year-old female with 15 years' history of rheumatoid arthritis developed nephrotic syndrome followed by rapid deterioration of renal function. Glomerular amyloid deposition and sclerotic change was present in kidney biopsy specimen and crescentic change was found in 85% of the glomerulus. Electron microscopic finding of glomerulus showed randomly oriented, rigid-appearing, long nonbranching fibrils. The patient was treated with intravenous high-dose methylprednisolone pulses combined with intravenous cyclophosphamide followed by oral corticosteroids. Three months after the above treatment, renal function gradually improved, reaching serum creatinine level to 2.5 mg/dL. But the nephrotic range proteinuria persisted.
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