Korean J Nephrol.  1998 Sep;17(5):813-817.

A Case of IgA Nephropathy Associated with Non-Hodgkin's Lymphoma

• Jeong YS
• Lee HJ
• Kim JS
• Lee EY
• Choi SO
• Lee CI
• Shim YH
• Hong SW

Abstract

The development of glomerular injury in patients with malignancy is considered as paraneoplastic syndrome. The most frequently observed renal lesions associated with malignancies are the membraneous glomerulonephritis on carcinomas and minimal change nephrotic syndrome on Hodgkin's disease. However, glomerular diseases on non-Hodgkin's lymphoma were only occasionally reported. Here we report a case of IgA nephropathy associated with non-Hodgkin's lymphoma. A 53-year-old woman who had complained of gross hematuria and fever was admitted to Wonju Christian Hospital. A urinalysis revealed 2+ proteinuria and red blood cells >30/HPF. A 24-hour urinary protein excretion was 379mg. She was diagnosed as IgA nephropathy on renal biopsy. Subsequently, biopsy of her enlarged neck node was performed for evaluation of fever of unknown origin and it revealed non-Hodgkin's lymphoma (Ki-1 positive anaplastic lymphoma null cell type). Combination chemotherapy was instituted with cyclophosphamide, adriamycin, vincristine and prednisone. After 3 cycles of chemotherapy, she showed no evidence of proteinuria and hematuria with clinical and radiological improvement of malignant lymphoma. Therefore we suggest of certain association between IgA nephropathy and non-Hodgkin's lymphoma by the observation of corresponding disease activity.

Keyword

IgA nephropathy; Non-Hodgkin's Lymphoma; Paraneoplastic syndrome

MeSH Terms

Biopsy
Cyclophosphamide
Doxorubicin
Drug Therapy
Drug Therapy, Combination
Erythrocytes
Female
Fever
Fever of Unknown Origin
Gangwon-do
Glomerulonephritis
Glomerulonephritis, IGA*
Hematuria
Hodgkin Disease
Humans
Immunoglobulin A*
Lymphocytes, Null
Lymphoma
Lymphoma, Non-Hodgkin*
Middle Aged
Neck
Nephrosis, Lipoid
Paraneoplastic Syndromes
Prednisone
Proteinuria
Urinalysis
Vincristine
Cyclophosphamide
Doxorubicin
Immunoglobulin A
Prednisone
Vincristine