Korean J Obstet Gynecol.
2006 Jun;49(6):1196-1203.
Serum Concentrations of Vascular Endothelial Growth Factor (VEGF) and placental VEGF expression in patients with preeclampsia
- Affiliations
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- 1Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans' University, Seoul, Korea. kkyj@ewha.ac.kr
- 2Department of Microbiology, College of Medicine, Ewha Womans' University, Seoul, Korea.
- 3Department of Preventive Medicine, College of Medicine, Ewha Womans' University, Seoul, Korea.
- 4Department of Anatomy, College of Medicine, Ewha Womans' University, Seoul, Korea.
- 5Ewha Medical Research Institute, College of Medicine, Ewha Womans' University, Seoul, Korea.
Abstract
OBJECTIVE
The goal of this study was to compare serum concentrations of VEGF, placental growth facto r(PlGF), soluble VEGF receptor-1 (sVEGFR-1) and the expression of VEGF-A in placental tissue from preeclamptic pregnancy with normal pregnancy.
METHODS
From pregnant women with (n=46) and without (n=40) preeclampsia, maternal serum in third trimester and placental tissue at delivery were collected. The serum concentrations of VEGF, PlGF, and sVEGFR-1 were measured. The expression levels of VEGF-A protein in placenta were assessed using Western blot.
RESULTS
The concentrations of total VEGF, PlGF were significantly decreased and that of sVEGFR-1 was significantly increased in patients with preeclampsia. The expression of VEGF-A protein was lower in preeclamptic placenta than in control placenta, but there was no significant difference.
CONCLUSION
The abnormality of angiogenic factors (VEGF, PlGF, sVEGFR-1) may be important in the development of pathophysiology of preeclampsia. An elevation of sVEGFR-1 may lead to suppression of VEGF and PlGF effects, and also the down-regulation of VEGF-A protein in placenta may result in the decreased maternal vascular adaptation to pregnancy.
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