The Relationship between Bone Mineral Density and Serum Lipid Profile in Postmenopausal Women

Kim, Jeong Seok; Cho, Sook; Yoon, Eun Mi; Choi, Young Mi; Choi, Beom; Kim, Dong Jin; Lee, Hun Jae

Abstract

OBJECTIVE
To assess the correlation of serum lipid profile with lumbar bone mineral density (BMD) in postmenopausal women and investigate whether serum lipid profile could be a risk factor of osteoporosis.
METHODS
From 1995 to 2003, we retrospectively reviewed 231 postmenopausal women, who did not take any drugs affecting lipid or bone metabolism. The hysterectomized women or metabolic disease patients were excluded. We analyzed the relationship between serum lipid profile and other parameters in normal and osteopenic groups based on lumbar BMD.
RESULTS
There was no significant relationship between serum lipid profile and lumbar BMD in univariate analysis (chi-squared test and Pearson correlation analysis). Lumbar BMD was correlated inversely with age (r=-0.355, p<0.001) and years since menopause (r=-0.399, p<0.001). The results using multiple logistic regression analysis didn't show the risk difference among subgroups divided by LDL-C level. Odds ratios for the group of moderate (130-159 mg/dL) and high (>or=160 mg/dL) LDL-C levels were 1.09 (95%CI: 0.58-2.05) and 1.10 (95%CI: 0.44-2.79), respectively, compared to normal (<130 mg/dL) LDL-C group.
CONCLUSION
There was no correlation between serum lipid profile and lumbar BMD. Serum lipid profile may not be a risk factor of osteoporosis, however, a prospective study in a larger group, considered with multiple factors, will be required to get more proper conclusions.