Korean J Otolaryngol-Head Neck Surg.  2007 Jan;50(1):37-42.

Prognostic Factors of Nasal NK/T Cell Lymphoma

• Kim DH
• Yoon JH
• Kang SO
• Park JS
• Hong SP
• Kahng H
• Kim HJ

Abstract

BACKGROUND AND OBJECTIVES
Nasal natural killer T (NK/T) cell lymphomas are relatively common in Asia, but the prognostic factors are not well known. The purpose of this research was therefore to evaluate those prognostic factors.
SUBJECTS AND METHOD
We reviewed and analyzed the medical records of 68 patients diagnosed as nasal NK/T cell lymphomas between 1984 and 2003 at Ajou University Hospital and at Yonsei University Hospital. Prognostic factors that include age, B symptoms, serum lactate dehydrogenase (LDH) levels, Eastern cooperative oncology group (ECOG) performance status, international prognostic indices (IPI), treatment modality, and Ann Arbor tumor stages were analyzed using the methods of univariate and multivariate statistics.
RESULTS
The five-year overall survival rate was 43%. By univariate analysis, we found ECOG performance status, Ann Arbor tumor stages, B symptoms, and IPI to be significant prognostic factors of nasal NK/T cell lymphoma. The multivariate analysis showed that ECOG performance status and B symptoms were significant.
CONCLUSION
ECOG performance status, Ann Arbor tumor stages, B symptoms, and IPI could all be prognostic factors of the nasal NK/T cell lymphoma. Among these factors, ECOG performance status and B symptoms may be regarded more useful in diagnosis of the disease than others.

Keyword

Nasal NK/T cell lymphoma; Prognostic factor; International prognostic index

MeSH Terms

Asia
Diagnosis
Humans
L-Lactate Dehydrogenase
Lymphoma*
Medical Records
Multivariate Analysis
Survival Rate
L-Lactate Dehydrogenase