Korean J Pathol.  2005 Dec;39(6):428-432.

Gangliocytic Paraganglioma

Affiliations
  • 1Department of Pathology, Inha University College of Medicine, Incheon, Korea. ycchu@inha.ac.kr
  • 2Department of Gastroenterology, Inha University College of Medicine, Incheon, Korea.
  • 3Department of General Surgery, Inha University College of Medicine, Incheon, Korea.

Abstract

Gangliocytic paraganglioma (GP) is a rare benign tumor that is usually seen in the duodenum. It shows unique histologic features that are composed of a carcinoid or paraganglioma-like appearance, ganglion cells, and Schwann cells. The common presenting symptoms are abdominal pain, gastrointestinal bleeding and obstruction. The lesion can sometimes be asymptomatic and they are discovered incidentally. We experienced a case of incidentally found GP in a 73 year-old-man who had a colon cancer with liver metastasis. During the preoperative workup, a submucosal tumor was found in the duodenal papilla. The frozen diagnosis of the duodenal mass was GP, which was confirmed by the permanent sections and immunohistochemical staining. Pathologists should be alert to recognize and diagnose this rare, but benign disease, especially in the patient suffering with gastrointestinal cancer.

Keyword

Gangliocytic paraganglioma; Carcinoid; Paraganglioma; Duodenal neoplasm; Immunohistochemistry

MeSH Terms

Abdominal Pain
Carcinoid Tumor
Colonic Neoplasms
Diagnosis
Duodenal Neoplasms
Duodenum
Ganglion Cysts
Gastrointestinal Neoplasms
Hemorrhage
Humans
Immunohistochemistry
Liver
Neoplasm Metastasis
Paraganglioma*
Schwann Cells
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