Korean J Pediatr.  2010 Jul;53(7):729-734. 10.3345/kjp.2010.53.7.729.

Genetics of kidney development: pathogenesis of renal anomalies

• Hahn H

• KMID: 2073602
• DOI: http://doi.org/10.3345/kjp.2010.53.7.729

Abstract

Congenital anomalies of the kidney and urinary tract (CAKUT) account for more than 50% of abdominal masses found in neonates and involve about 0.5% of all pregnancies. CAKUT has a major role in renal failure, and increasing evidence suggests that certain abnormalities predispose to the development of hypertension and cardiovascular disease in adulthood. To understand the pathogenesis of human renal anomalies, understanding the development of kidney is important. Diverse anomalies of the kidney corresponding to defects at a particular stage of development have been documented recently; however, more research is required to understand the molecular networks underlying kidney development, and such an investigation will provide a clue to the therapeutic intervention for CAKUT.

Keyword

Congenital anomalies; Development; Urinary tract; Kidney

MeSH Terms

Cardiovascular Diseases
Humans
Hypertension
Infant, Newborn
Kidney
Pregnancy
Renal Insufficiency
Urinary Tract
Vesico-Ureteral Reflux
Vesico-Ureteral Reflux