Korean J Perinatol.
1999 Dec;10(4):460-464.
Intravaginal Misoprostol for the Termination of Second and Third Trimester Pregnancy
Abstract
OBJECTIVE
The purpose was to evaluate the effect of the intravaginal misoprostol(prostaglandin E1,) for termination after second trimester.
METHODS
Thirty pregnant women with intrauterine fetal death and with indications for therapeutic termination of intrauterine pregnancy at least fourteen weeks of gestation were recruited. They were evaluated the mean time from induction to termination, maternal side effects, and total dose of the powdered 100ug misoprostol adminstered in the posterior vaginal fornix every six hours.
RESULTS
The mean time from induction to termination was 21.1+/-8.2 hours after administration of the intravaginal misoprostol. Only two patients had not been delivered within 48hours. Vomiting, diarrhea, and fever were not accompanied except nausea. The total dosage of misoprostol was 412.5+/-156.1ug.
CONCLUSION
This study shows that intravaginal misoprostol appears to be safe, effective and inexpensive method for the labor induction for termination of pregnancy in the second or third trimester of pregnancy.
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