Korean J Reprod Med.  2010 Sep;37(3):239-244.

Comparison between GnRH Antagonist and Agonist Long Protocols in Poor Responders

• Choi JY
• Ku SY
• Kim H
• Jee BC
• Suh CS
• Kim SH
• Choi YM
• Kim JG
• Moon SY

Abstract

OBJECTIVE
The objective of this retrospective study was to compare the in vitro fertilization (IVF) outcomes of gonadotropinreleasing hormone (GnRH) agonist and GnRH antagonist protocols in poor responders. METHODS: A total of 172 cycles in subjects with less than 5 oocytes retrieved treated with either GnRH agonist long protocols or antagonist protocols were included. The outcome variables such as numbers of growing follicles and retrieved oocytes, and the fertilization rate were evaluated as the main outcome measures. RESULTS: There was no difference in regard to the numbers of growing follicles and oocytes, and fertilization rate between the two groups. E2 level on Day 7/8, mean gonadotropin dose, and the days of stimulation were shown to be statistically different (p<0.01, respectively). CONCLUSION: Considering that similar results were observed with less time and gonadotropin dose, GnRH antagonist protocol may be considered as a preferable choice over GnRH agonist protocols in poor responders.

Keyword

Poor responder; Gonadotropin-releasing hormone agonist; GnRH antagonist; Controlled ovarian hyperstimulation; in vitro fertilization

MeSH Terms

Fertilization
Fertilization in Vitro
Gonadotropin-Releasing Hormone
Gonadotropins
Oocytes
Outcome Assessment (Health Care)
Retrospective Studies
Gonadotropin-Releasing Hormone
Gonadotropins