Clin Mol Hepatol.  2014 Dec;20(4):398-401. 10.3350/cmh.2014.20.4.398.

Reversible splenial lesion on the corpus callosum in nonfulminant hepatitis A presenting as encephalopathy

• Ko SY
• Kim BK
• Kim DW
• Kim JH
• Choe WH
• Seo HY
• Kwon SY

• KMID: 2070259
• DOI: http://doi.org/10.3350/cmh.2014.20.4.398

Abstract

Reversible focal lesions on the splenium of the corpus callosum (SCC) have been reported in patients with mild encephalitis/encephalopathy caused by various infectious agents, such as influenza, mumps, adenovirus, Varicella zoster, Escherichia coli, Legionella pneumophila, and Staphylococcus aureus. We report a case of a reversible SCC lesion causing reversible encephalopathy in nonfulminant hepatitis A. A 30-year-old healthy male with dysarthria and fever was admitted to our hospital. After admission his mental status became confused, and so we performed electroencephalography (EEG) and magnetic resonance imaging (MRI) of the brain, which revealed an intensified signal on diffusion-weighted imaging (DWI) at the SCC. His mental status improved 5 days after admission, and the SCC lesion had completely disappeared 15 days after admission.

Keyword

Acute hepatitis A; Encephalopathy; Magnetic resonance imaging; Corpus callosum

MeSH Terms

Adult
Alanine Transaminase/blood
Corpus Callosum/*radiography
Creatinine/blood
Electroencephalography
Encephalitis/complications/*diagnosis
Hepatitis A/complications/*diagnosis
Humans
Magnetic Resonance Imaging
Male
Renal Dialysis
Alanine Transaminase
Creatinine