Yonsei Med J.  2015 Mar;56(2):578-581. 10.3349/ymj.2015.56.2.578.

Bronchiolitis Obliterans Associated with Stevens-Johnson Syndrome: A Case Report

Affiliations
  • 1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 2Division of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 3Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. cmlim@amc.seoul.kr

Abstract

We report a case of bronchiolitis obliterans associated with Stevens-Johnson syndrome. A 59-year-old man presented with respiratory distress that gradually worsened over 3 months. He had been diagnosed with Stevens-Johnson syndrome 3 months before admission. He had no history of previous airway disease. On physical examination, expiratory breathing sounds were not audible, and a chest X-ray revealed a hyperinflated lung. A pulmonary function test indicated a severe obstructive pattern. Computed tomography scans of inspiratory and expiratory phases of respiration showed oligemia and air trapping, and both were more prominent on expiration view than on inspiration view. The pathogenesis of bronchiolitis obliterans associated with Stevens-Johnson syndrome is largely unknown.

Keyword

Stevens-Johnson syndrome; bronchiolitis obliterans; dyspnea

MeSH Terms

Anti-Bacterial Agents/therapeutic use
Bronchiolitis Obliterans/etiology/*radiography/therapy
Bronchoscopy
Dyspnea/*complications
Fatal Outcome
Humans
Male
Middle Aged
Radiography, Thoracic
Respiratory Distress Syndrome, Adult/*etiology/therapy
Respiratory Function Tests
Roxithromycin/therapeutic use
Stevens-Johnson Syndrome/*complications/drug therapy
Tomography, X-Ray Computed/methods
Tracheostomy
Anti-Bacterial Agents
Roxithromycin
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