J Korean Med Sci.  2014 Dec;29(12):1651-1657. 10.3346/jkms.2014.29.12.1651.

Mid-Term Outcomes in Patients Implanted with Cardiac Resynchronization Therapy

• Lee SH
• Park SJ
• Kim JS
• Shin DH
• Cho DK
• On YK

• KMID: 2069954
• DOI: http://doi.org/10.3346/jkms.2014.29.12.1651

Abstract

We applied cardiac resynchronization therapy (CRT) for desynchronized heart failure patients. We evaluated clinical outcomes including morbidity, mortality, and echocardiographic parameters in 47 patients with implanted CRT in Korea from October 2005 to May 2013. The combined outcomes of hospitalization from heart failure, heart transplantation and death were the primary end point. Median follow-up period was 17.5 months. The primary outcomes listed above occurred in 10 (21.3%) patients. Two patients (4.3%) died after CRT and 8 (17%) patients were hospitalized for recurrent heart failure. Among patients hospitalized for heart failure, 2 (4.3%) patients underwent heart transplantation. The overall free rate of heart failure requiring hospitalization was 90.1% (95% CI, 0.81-0.99) over one year and 69.4% (95% CI, 0.47-0.91) over 3 yr. We observed improvement of the New York Heart Association classification (3.1+/-0.5 to 1.7+/-0.4), decreases in QRS duration (169.1 to 146.9 ms), decreases in left ventricular (LV) end-diastolic (255.0 to 220.1 mL) and end-systolic (194.4 to 159.4 mL) volume and increases in LV ejection fraction (22.5% to 31.1%) at 6 months after CRT. CRT improved symptoms and echocardiographic parameters in a relatively short period, resulting in low mortality and a decrease in hospitalization due to heart failure.

Keyword

Cardiac Resynchronization Therapy; Echocardiography; Heart Failure

MeSH Terms

Age Distribution
Cardiac Resynchronization Therapy/*mortality
Cardiac Resynchronization Therapy Devices/*statistics & numerical data
Female
Heart Failure/diagnosis/*mortality/*prevention & control
*Hospital Mortality
Hospitalization/*statistics & numerical data
Humans
Longitudinal Studies
Male
Middle Aged
Prevalence
Prostheses and Implants/statistics & numerical data
Recurrence
Republic of Korea/epidemiology
Risk Factors
Sex Distribution
Survival Rate
Treatment Outcome

Figure

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  Fig. 1 Comparison of changes in echocardiographic, electrocardiographic, and NT-pro BNP parameters before and after CRT.

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  Fig. 2 Kaplan-Meier curve of the free rate of hospitalization from heart failure, heart transplantation and death, along with composite primary outcomes.

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