Korean J Urol.  2014 Oct;55(10):690-692. 10.4111/kju.2014.55.10.690.

Unclassified Mucinous Renal Cell Carcinoma: A Rare Histopathological Entity

Affiliations
  • 1Department of Urology, University of California, San Diego Medical Center, San Diego, California, USA. oraheem@ucsd.edu
  • 2Department of Pathology, University of California, San Diego Medical Center, San Diego, California, USA.

Abstract

Renal cell carcinoma (RCC) with mucin production is extremely rare. We present the case of a previously healthy 76-year-old woman who underwent a robotic-assisted laparoscopic right nephrectomy for a 5-cm heterogeneously enhancing right renal mass. Pathology revealed mucin-producing epithelial RCC. We discuss the presentation and pathological features of this case and comment on its definitive treatment.

Keyword

Mucin; Renal cell carcinoma

MeSH Terms

Adenocarcinoma, Mucinous/*pathology/radiography/surgery
Aged
Carcinoma, Renal Cell/*pathology/radiography/surgery
Female
Humans
Kidney Neoplasms/*pathology/radiography/surgery
Nephrectomy/methods
Robotic Surgical Procedures/methods
Tomography, X-Ray Computed

Figure

  • FIG. 1 Transverse section of a computed tomography urogram showing a heterogeneous parenchymal right exophytic renal mass suspicious of renal cell carcinoma.

  • FIG. 2 The tumor displayed variable architectural patterns including areas of compact alveoli of clear cells consistent with clear cell carcinoma (×20).

  • FIG. 3 Glandular lumens contained blue mucin that was positive on mucicarmine stain (×20).

  • FIG. 4 Glandular lumens contained blue mucin that was positive on periodic acid-Schiff diastase stain (×20).


Reference

1. Val-Bernal JF, Salcedo W, Val D, Parra A, Garijo MF. Mucin-secreting clear cell renal cell carcinoma. A rare variant of conventional renal cell carcinoma. Ann Diagn Pathol. 2013; 17:226–229.
2. Grignon DJ, Ro JY, Ayala AG. Primary mucin-secreting adenocarcinoma of the kidney. Arch Pathol Lab Med. 1988; 112:847–849.
3. Eble JN, Sauter G, Epstein JI, Sesterhenn IA. Pathology and genetics tumors of the urinary system and male genital organs. Lyon: IARC Press;2004.
4. Lopez-Beltran A, Kirkali Z, Montironi R, Blanca A, Algaba F, Scarpelli M, et al. Unclassified renal cell carcinoma: a report of 56 cases. BJU Int. 2012; 110:786–793.
5. Karakiewicz PI, Hutterer GC, Trinh QD, Pantuck AJ, Klatte T, Lam JS, et al. Unclassified renal cell carcinoma: an analysis of 85 cases. BJU Int. 2007; 100:802–808.
6. Fine SW, Argani P, DeMarzo AM, Delahunt B, Sebo TJ, Reuter VE, et al. Expanding the histologic spectrum of mucinous tubular and spindle cell carcinoma of the kidney. Am J Surg Pathol. 2006; 30:1554–1560.
7. Lopez-Beltran A, Scarpelli M, Montironi R, Kirkali Z. 2004 WHO classification of the renal tumors of the adults. Eur Urol. 2006; 49:798–805.
8. Crispen PL, Tabidian MR, Allmer C, Lohse CM, Breau RH, Blute ML, et al. Unclassified renal cell carcinoma: impact on survival following nephrectomy. Urology. 2010; 76:580–586.
9. Zisman A, Chao DH, Pantuck AJ, Kim HJ, Wieder JA, Figlin RA, et al. Unclassified renal cell carcinoma: clinical features and prognostic impact of a new histological subtype. J Urol. 2002; 168:950–955.
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